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Subscribe: In this episode of The Oprah Podcast, Oprah sits down with Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, to talk about the new GLP-1 medications like Ozempic, Wegovy, Mounjaro and Zepbound. Dr. Ania, who has been on the forefront of GLP-1 medication research for the past 20 years, will talk through why it is biologically difficult for some people to lose weight, maintain weight loss, and why obesity is a disease. She explains how the new GLP-1 medications work, how they can facilitate weight loss, and if they are safe. Dr. Ania answers questions from people around the country who are taking the GLP-medications and have lost a significant amount of weight. We will also share an update from Amy Kane who told her story of losing 160 pounds on weight loss medications last year on Oprah’s ABC Special: Shame, Blame and the Weight Loss Revolution. 00:00:00 Welcome Dr. Ania Jastreboff 00:01:34 The difference between obesity and being overweight 00:03:14 Is obesity a disease? 00:05:33 Why are some people prone to obesity and not others? 00:08:28 How your brain plays a role in obesity 00:10:31 We eat more food than our bodies need 00:13:00 Oprah shares about being publicly shamed for her weight 00:14:20 Can we control our weight? 00:20:18 Why GLP-1 medications are a game-changer for so many people 00:20:58 How GLP-1 medications work 00:23:35 Amy joins Oprah to share her weight loss journey 00:26:11 The biggest misconceptions about GLP-1 weight loss drugs 00:29:00 Understanding food noise 00:31:12 Amina joins Oprah to share her weight loss journey 00:33:35 Do you need to stay on GLP-1 medications forever? 00:37:03 GLP-1 medications are not a weight loss drug 00:39:41 Emma joins Oprah to share her weight loss journey 00:42:58 Long-term effects of taking GLP-1 medications 00:48:23 Side effects of GLP-1 Also referenced in this episode: "The Let Them Theory: A Life-Changing Tool That Millions of People Can’t Stop Talking About" by Mel Robbins, published by Hay House LLC is available wherever books and audio books are sold: SUPPORT THE SHOW Subscribe: Find Oprah’s Interview with Mel Robbins here: Follow Amy on Instagram: Follow Amy on TikTok Follow Emma on TikTok Follow Emma on Instagram Follow Oprah Winfrey on Social: Listen to the full podcast: