Diabetes Medication Side Effects: Metformin, Sulfonylurea & Insulin – Dr.Berg [dcc65f]

2025-09-13

From A1c to eAG: A Simple Way to Understand Your Average Blood Glucose

Understanding your blood glucose levels is critical for managing diabetes and maintaining overall health. While you might check your blood sugar at various points throughout the day, two important measurements provide a blood sugar level in the morning broader picture: A1c and eAG (estimated Average Glucose). This article simplifies the connection between these two, making it easier for you to interpret your results and work with your healthcare provider.

What is A1c?

A1c, also known as glycated hemoglobin, is a blood test that reflects your average blood sugar levels over the past 2-3 months. Unlike a single blood sugar reading that fluctuates based on recent meals and activity, A1c provides a long-term perspective. Glucose in blood sugar chart with age your bloodstream attaches to hemoglobin, the protein in red blood cells that carries oxygen. The more glucose in your blood, the more glycated hemoglobin you'll have. Since red blood cells live for about three months, the A1c test captures this average glucose exposure.

Why is A1c Important?

The A1c test is crucial because it helps:

  • Diagnose prediabetes and diabetes: A1c levels can indicate if you have prediabetes (higher than normal blood sugar, but not high enough for a diabetes diagnosis) or diabetes.
  • Monitor diabetes management: For those already diagnosed with diabetes, the A1c test helps track how well your treatment plan is working.
  • Reduce the risk of long-term complications: By keeping your A1c within the target range recommended by your doctor, you can significantly lower your risk of developing diabetes-related complications like heart disease, kidney disease, nerve damage (neuropathy), and eye damage (retinopathy).

What is eAG?

eAG, or estimated Average Glucose, provides the same information as A1c, but it presents the data in a way that is easier for some people to understand. Instead of a percentage, eAG expresses your average blood sugar level in the same units that you use when checking your blood sugar throughout the day: milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L), depending on your location. Think of eAG as the average of all your daily blood sugar readings over the past few months.

Why Use eAG?

Many people find eAG more intuitive because:

  • Familiar Units: It uses the same units as your daily blood sugar readings, making it easier to relate to.
  • Easy Comparison: It allows you to compare your average blood sugar level (eAG) directly to individual blood sugar readings you take at home.
  • Improved Understanding: For some individuals, understanding blood sugar in mg/dL (or mmol/L) rather than a percentage can make diabetes management less daunting.

The Connection Between A1c and eAG

A1c and eAG are directly related; one is simply a different way of expressing the other. A mathematical formula converts your A1c percentage into an estimated average glucose value (eAG). You don’t need to memorize the formula; labs often provide both A1c and eAG values on your test results.

Below is a table illustrating the typical relationship between A1c and eAG.

A1c (%) eAG (mg/dL) eAG (mmol/L)
6.0% 126 mg/dL 7.0 mmol/L
7.0% 154 mg/dL 8.6 mmol/L
8.0% 183 mg/dL 10.1 mmol/L
9.0% 212 mg/dL 11.8 mmol/L
10.0% 240 mg/dL 13.4 mmol/L

Understanding Your Target Ranges

The ideal target range for both A1c and eAG depends on various factors, including:

  • Age: Target ranges may be different for children, adults, and older adults.
  • Type of diabetes: Target ranges can vary depending on whether you have type 1, type 2, or gestational diabetes.
  • Overall health: Other medical conditions can influence your target A1c and eAG levels.
  • Individual circumstances: Your doctor will consider your individual needs and preferences when setting your goals.

Generally, for non-pregnant adults with diabetes, the American Diabetes Association (ADA) recommends an A1c of less than 7%, which corresponds to an eAG of less than 154 mg/dL (8.6 mmol/L). However, your individual target may be higher or lower, so it's essential to discuss this with your doctor.

Here's a summary table showing general target ranges:

Measurement General Target (Non-Pregnant Adults with Diabetes)
A1c Less than 7%
eAG Less than 154 mg/dL (8.6 mmol/L)

Important Note: These are general guidelines only. Always consult with your healthcare provider to determine your individual target ranges.

Factors That Can Affect A1c and eAG Results

Several factors can influence A1c and eAG results, including:

  • Certain medical conditions: Anemia, kidney disease, and liver disease can affect A1c results.
  • Hemoglobin variants: Certain types of hemoglobin can interfere with the accuracy of the A1c test.
  • Medications: Some medications, like iron supplements, can also influence A1c levels.
  • Ethnicity: Some studies suggest that A1c levels may vary slightly among different ethnic groups.

If you have any of these conditions or are taking medications that might affect your A1c, be sure to inform your doctor. They may need to use alternative methods to monitor your blood sugar control, such as continuous glucose monitoring (CGM).

Practical Steps for Improving Your A1c and eAG

Lowering your A1c and eAG involves a combination of lifestyle changes and, in some cases, medication. Here are some practical steps you can take:

  1. Follow a healthy eating plan: Work with a registered dietitian or diabetes educator to develop a meal plan that is tailored to your needs. Focus on consuming whole, unprocessed foods, including plenty of fruits, vegetables, and whole grains. Limit your intake of sugary drinks, processed snacks, and refined carbohydrates.
  2. Get regular physical activity: Aim for at least 150 minutes of moderate-intensity aerobic exercise per week, such as brisk walking, cycling, or swimming. Incorporate strength training exercises at least twice a week to build muscle mass and improve insulin sensitivity.
  3. Monitor your blood sugar regularly: Checking your blood sugar as directed by your doctor can help you understand how your body responds to different foods, activities, and medications. This information can help you make informed decisions about your diabetes management.
  4. Take your medications as prescribed: If your doctor has prescribed medication to manage your diabetes, take it exactly as directed. Do not skip doses or change the dosage without talking to your doctor first.
  5. Manage stress: Chronic stress can raise blood sugar levels. Find healthy ways to manage stress, such as practicing relaxation techniques, spending time in nature, or 159 blood sugar before eating engaging in hobbies you enjoy.
  6. Get enough sleep: Lack of sleep can disrupt blood sugar control. Aim for 7-8 hours of quality sleep each night.

Working with Your Healthcare Team

Regular communication with your healthcare team is crucial for managing your diabetes effectively. Here are some ways to collaborate with your doctor, diabetes educator, and registered dietitian:

  • Discuss your A1c and eAG goals: Work with your doctor to set realistic target ranges that are tailored to your individual needs.
  • Review your blood sugar logs: Share your blood sugar records with your healthcare team to identify patterns and make adjustments to your treatment plan.
  • Ask questions: Don't hesitate to ask your healthcare team questions about your diabetes management. They are there to support you and provide guidance.
  • Attend regular appointments: Schedule regular checkups with your doctor to monitor your overall health and make any necessary adjustments to your treatment plan.

Conclusion

Understanding the relationship between A1c and eAG is crucial for effective diabetes management. While A1c provides a broader perspective of average blood glucose over 2-3 months, eAG presents this information in a more relatable and understandable format. By working closely with your healthcare provider, monitoring your blood sugar levels, and adopting healthy lifestyle habits, you can effectively manage your diabetes and minimize your risk of long-term complications. Remember, proactive management and continuous learning are key to living a long and healthy life with diabetes.

Get access to my FREE resources 👉 I explain the side effects of diabetes medications. Timestamps: 0:00 What effects do diabetes medications have on your body? 0:56 There are 3 different effects that certain medications create in this scenario 3:00 Metformin increases the sensitivity of your insulin receptors In this video, I explain the effects of type 2 diabetes medications on your body. Your pancreas makes the hormone insulin, which travels through your blood. Insulin responds to carbohydrates; less so to protein. Its goal is to lower your blood sugar. Insulin is received by what’s called an insulin receptor. As I said, one goal is to lower blood sugar. Another is to store glycogen (sugar), cholesterol, or fat. There are 3 different effects these medications create in this scenario. One is that they increase the production of insulin. One popular medication is called sulfonylurea, but it works only for type 2 diabetes, not type 1. The problem with this medication is that it’s also used as an herbicide. It increases your risk of cardiovascular disease and death. Another mechanism works on the insulin receptor. People with type 2 diabetes have insulin resistance, meaning their receptors aren’t taking in insulin very well. This creates a failure in the feedback loop to the body, which ends up getting the message to produce more and more insulin. The more the receptor is resistant, the more insulin the pancreas is going to produce. If you’re taking a sulfonylurea, which increases insulin production, your insulin levels are going to get quite high. Metformin increases the sensitivity of your receptors; that is, they can receive more insulin. A black label on metformin warns of the dangers of a condition called lactic acidosis, a serious condition that causes your pH to go way up. A natural remedy for this condition is vitamin B1. The problem is that metformin depletes B1. Many type 2 diabetics are given insulin. The problem is that the pancreas is already producing too much insulin because of insulin resistance. So too much insulin is being dumped into the system for the purpose of lowering blood sugar. And it comes with the risk of cardiovascular disease, weight gain, and hypoglycemia (low blood sugar). With hypoglycemia, you become irritable and shaky and want to eat carbs to raise your blood sugar back up, starting the whole cycle over again. Now you can see the effects of diabetes medications on your body. Dr. Eric Berg DC Bio: Dr. Berg, age 56, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media. Follow us on FACEBOOK: fb.me/DrEricBerg ABOUT DR. BERG: Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. The Health & Wellness, Dr. Berg Nutritionals and Dr. Eric Berg, D.C. are not liable or responsible for any advice, course of treatment, diagnosis or any other information, services, or product you obtain through this video or site. Thanks for watching! Diabetes medications can cause numerous side effects.
Diabetes Medication Side Effects: Metformin, Sulfonylurea & Insulin – Dr.Berg